Endocrine Abstracts

The effect of Oestrogen on brain aging. Declan GM Murphy.The biological basis of human brain aging is poorly understood and there are few proven treatments for age-related brain disease. Recently, however, it has been suggested that HRT may have a 'neuroprotective' effect. Some studies report no beneficial effect of HRT on cognitive function in healthy older women though most show a significant benefit to memory and/or a general cognitive enhancement. There is perhaps grea...

Objective: PCOS affects approximately 10% of women of reproductive age. We have audited the management of women attending the multidisciplinary PCOS clinic at the Royal Berkshire Hospital which was set up in September 2002.Methods: Data on women attending the PCOS clinic at the Royal Berkshire Hospital between September 2002 and September 2004 were analysed. Points investigated were: baseline characteristics, adequacy of investigations and efficacy of tr...

Background: Adipogenesis is a key process leading to adipose tissue (AT) expansion. However, managing this event is critical to limit excessive fat accumulation and disease risk. Adipogenesis appears controlled in part, through Wnt10b signalling which reduces adipogenesis via inhibiting CCAAT/enhancer-binding protein alpha (CEBPα) although the molecular mechanism remains unclear.Aims: Abdominal subcutaneous AT (AbdSc AT) was collected from a, non-di...